Histological dating endometrium

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Also, it has been stressed that chronological dating should be assigned prospectively rather than retrospectively to avoid inaccuracies caused by the variable length of the luteal phase and the accelerated onset of menses induced by the procedure.Thus, ultrasonographic studies have shown that the accuracy of histological endometrial dating is best determined when ovulation is detected by that method (6, 7).The histologic features of what constitutes “normal” endometrium change with a woman’s age, through the premenarchal, reproductive, perimenopausal, and postmenopausal years.During the reproductive years, the cyclical hormonal changes of the menstrual cycle provide a continuously changing morphologic phenotype that is “normal.” In biopsy specimens, the combination of these cyclical changes along with artifacts and limited sampling can make normal patterns difficult to interpret.

6–8 d after ovulation) is more sensitive for identifying altered patterns of endometrial maturation (3–5).It has been proposed that the in phase endometrium may exhibit aberrant behavior, not correlated with histological delay, yet still be associated with decreased cycle fecundity (11).Markers of normal endometrial development are being uncovered that, according to some authors, will allow us to go beyond merely histological criteria in the evaluation of endometrial function and receptivity.It has been accepted that the endometrial biopsy, properly obtained and properly diagnosed, can serve as a bioassay.If the biopsy is obtained as close to the expected menses as possible, almost the entire steroidogenic function of the corpus luteum is reflected in the endometrial histological pattern.

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